Journal article
Diversity and clonotypic composition of influenza-specific CD8 TCR repertoires remain unaltered in the absence of Aire
K Kedzierska, SA Valkenburg, C Guillonneau, FX Hubert, T Cukalac, JM Curtis, J Stambas, HS Scott, L Kedzierski, V Venturi, MP Davenport
European Journal of Immunology | WILEY-BLACKWELL | Published : 2010
Abstract
TCR repertoire diversity is important for the protective efficacy of CD8+ T cells, limiting viral escape and cross-reactivity between unrelated epitopes. The exact mechanismfor selection of restricted versus diverse TCR repertoires is far from clear, although one thought is that the epitopes resembling self-peptides might select a limited array of TCR due to the deletion of autoreactive TCR. The molecule Aire promotes the expression of tissue-specific Ag on thymic medullary epithelial cells and the deletion of autoreactive cells, and in the absence of Aire autoreactive cells persist. However, the contribution of Aire-dependent peptides to the selection of the Ag-specific TCR repertoire remai..
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Awarded by Australian National Health and Medical Research Council (NHMRC)
Awarded by Australian Research Council Discovery
Awarded by 6th FP of the EU
Funding Acknowledgements
We would like to thank Ken Field for his help with the FAGS sorting and Natasha Swan for technical assistance. This work was supported by an Australian National Health and Medical Research Council (NHMRC) Project Grant 454312 awarded to K. K., 406631 awarded to L. K. and Australian Research Council Discovery Project grant (DPO 0771340) to M. P. D. and V. V. M. P. D. is a Sylvia and Charles Viertel Senior Medical Research Fellow, K. K. is an NHMRC RD Wright Research Fellow, C. G. and F. X. H. are supported by a fellowship from the 6th FP of the EU, Marie Curie, 040840 and 040998, respectively, and V. V. is an ARC Future Fellow. S. A. V. is a recipient of the Australian Postgraduate Award; T. C. is a recipient of the NHMRC Biomedical Postgraduate Scholarship 520643.